Huang Tannie, Ducore Jonathan M
Department of Pediatrics, University of California, Davis School of Medicine, Sacramento, CA.
J Pediatr Hematol Oncol. 2014 Jan;36(1):16-21. doi: 10.1097/MPH.0b013e31829bcb10.
We investigated whether the relative increased height of childhood acute lymphoblastic leukemia (ALL) survivors at diagnosis was due to referral bias, the height of California children, socio-economic status, or race/ethnicity. We reviewed the records of all Pediatric Oncology referrals to our institution from 1988 to 2007. Height at diagnosis, sex, age at and date of diagnosis, date of birth, diagnosis, race/ethnicity, and socio-economic status were evaluated. Heights were standardized by z score from age and sex norms for US children. Of the 883 cases, 180 were excluded (Down syndrome, noncancer diagnosis, data at relapse only, incorrect height measurement, or major growth disturbance). ALL patients were taller than those with other cancers and US children. Age at and date of diagnosis and date of birth had no effect. Whites, boys, and those with private insurance had higher height z scores. Multivariable analysis identified diagnosis and race/ethnicity as significant. ALL children and adolescents were taller and black and Asian children shorter than white children. The mean height increase for those with ALL was 1.3 cm. The reason for the increased height of these patients is unknown, but is not due to referral patterns, having childhood cancer, or the racial/ethnic makeup of California children.
我们调查了儿童急性淋巴细胞白血病（ALL）幸存者在诊断时相对身高增加是否归因于转诊偏倚、加利福尼亚州儿童的身高、社会经济地位或种族/民族。我们回顾了1988年至2007年转诊至我们机构的所有儿科肿瘤病例记录。评估了诊断时的身高、性别、诊断年龄和日期、出生日期、诊断、种族/民族以及社会经济地位。根据美国儿童的年龄和性别标准，通过z评分对身高进行标准化。在883例病例中，排除了180例（唐氏综合征、非癌症诊断、仅复发时的数据、身高测量错误或严重生长障碍）。ALL患者比其他癌症患者和美国儿童更高。诊断年龄和日期以及出生日期没有影响。白人、男孩以及有私人保险的人身高z评分更高。多变量分析确定诊断和种族/民族具有显著性。ALL儿童和青少年比白人儿童更高，而黑人及亚洲儿童比白人儿童更矮。ALL患者的平均身高增加了1.3厘米。这些患者身高增加的原因尚不清楚，但并非由于转诊模式、患儿童癌症或加利福尼亚州儿童的种族/民族构成。
