乳腺癌的遗传异质性：通向个体化医学之路？
Genetic heterogeneity in breast cancer: the road to personalized medicine?
机构信息
Department of Oncology, University of Cambridge, Addenbrooke's Hospital, Hills Road, Box 97, Cambridge CB4 3EJ, UK.
出版信息
BMC Med. 2013 Jun 18;11:151. doi: 10.1186/1741-7015-11-151.
Abstract
More women die from breast cancer across the world today than from any other type of malignancy. The clinical course of breast cancer varies tremendously between patients. While some of this variability is explained by traditional clinico-pathological factors (including patient age, tumor stage, histological grade and estrogen receptor status), molecular profiling studies have defined breast cancer subtypes with distinct clinical outcomes. This mini-review considers recent studies which have used genomics technologies in an attempt to identify new biomarkers of prognosis and treatment response. These studies highlight the genetic heterogeneity that exists within breast cancers in space and time.
摘要
如今，全世界死于乳腺癌的女性比死于其他任何类型恶性肿瘤的女性都多。乳腺癌的临床病程在患者之间差异巨大。虽然这种变异性有一部分可以用传统的临床病理因素来解释（包括患者年龄、肿瘤分期、组织学分级和雌激素受体状态），但分子谱分析研究已经确定了具有不同临床结局的乳腺癌亚型。这篇综述考虑了最近使用基因组学技术试图识别新的预后和治疗反应生物标志物的研究。这些研究强调了乳腺癌在空间和时间上存在的遗传异质性。
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