McGrath Lindsay A, Whitehead Kevin, Lee Graham A
City Eye Centre, Brisbane, Queensland, Australia; University of Queensland, Brisbane, Queensland, Australia.
Clin Exp Optom. 2014 Mar;97(2):184-6. doi: 10.1111/cxo.12077. Epub 2013 Jun 25.
The Splendore-Hoeppli reaction is a rare phenomenon characterised by the formation of eosinophilic material around infectious or non-infectious agents. A 33-year-old patient with persistent Splendore-Hoeppli phenomenon was previously treated with topical steroids but this resulted in a rise in intraocular pressure. The patient was treated with topical cyclosporin A one per cent twice daily as an alternative immunosuppression. After three weeks of treatment the patient had complete resolution of her conjunctival granuloma. This case report introduces cyclosporin A as a treatment option for the Splendore-Hoeppli phenomenon. This is a safe drug for long-term topical use in this condition.
斯普伦多雷-赫普利反应是一种罕见现象，其特征是在感染性或非感染性病原体周围形成嗜酸性物质。一名患有持续性斯普伦多雷-赫普利现象的33岁患者此前接受了局部类固醇治疗，但这导致眼压升高。该患者接受了1%的局部环孢素A治疗，每天两次，作为替代免疫抑制治疗。治疗三周后，患者的结膜肉芽肿完全消退。本病例报告介绍了环孢素A作为斯普伦多雷-赫普利现象的一种治疗选择。在这种情况下，这是一种可长期局部使用的安全药物。
