Nat Genet. 2013 Jul;45(7):717-8. doi: 10.1038/ng.2680.
Transposable elements (TEs) make up 50% of the human genome and are usually considered a mutational burden. A new study uses signatures of DNA hypomethylation to identify tissue-specific enhancers within TEs, providing fresh evidence that mobile DNA has a non-negligible role in genome regulation and evolution.
转座元件(TEs)构成了人类基因组的 50%,通常被认为是一种突变负担。一项新的研究利用 DNA 低甲基化的特征来识别 TEs 中的组织特异性增强子,为移动 DNA 在基因组调控和进化中具有不可忽视的作用提供了新的证据。