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单纯疱疹病毒 1 型和内源性逆转录病毒作为脱髓鞘的危险因素。

HSV-1 and Endogenous Retroviruses as Risk Factors in Demyelination.

机构信息

Departamento de Biología Molecular, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Cantoblanco, 28049 Madrid, Spain.

出版信息

Int J Mol Sci. 2021 May 27;22(11):5738. doi: 10.3390/ijms22115738.

DOI:10.3390/ijms22115738
PMID:34072259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8199333/
Abstract

Herpes simplex virus type 1 (HSV-1) is a neurotropic alphaherpesvirus that can infect the peripheral and central nervous systems, and it has been implicated in demyelinating and neurodegenerative processes. Transposable elements (TEs) are DNA sequences that can move from one genomic location to another. TEs have been linked to several diseases affecting the central nervous system (CNS), including multiple sclerosis (MS), a demyelinating disease of unknown etiology influenced by genetic and environmental factors. Exogenous viral transactivators may activate certain retrotransposons or class I TEs. In this context, several herpesviruses have been linked to MS, and one of them, HSV-1, might act as a risk factor by mediating processes such as molecular mimicry, remyelination, and activity of endogenous retroviruses (ERVs). Several herpesviruses have been involved in the regulation of human ERVs (HERVs), and HSV-1 in particular can modulate HERVs in cells involved in MS pathogenesis. This review exposes current knowledge about the relationship between HSV-1 and human ERVs, focusing on their contribution as a risk factor for MS.

摘要

单纯疱疹病毒 1 型（HSV-1）是一种嗜神经的α疱疹病毒，可感染外周和中枢神经系统，并与脱髓鞘和神经退行性过程有关。转座元件（TEs）是可以从一个基因组位置移动到另一个基因组位置的 DNA 序列。TEs 与几种影响中枢神经系统（CNS）的疾病有关，包括多发性硬化症（MS），这是一种病因不明的脱髓鞘疾病，受遗传和环境因素的影响。外源性病毒转录激活因子可能会激活某些逆转录转座子或 I 类 TEs。在这种情况下，几种疱疹病毒与 MS 有关，其中一种 HSV-1 可能通过介导分子模拟、髓鞘再生和内源性逆转录病毒（ERVs）的活性等过程作为危险因素发挥作用。几种疱疹病毒参与了人类 ERVs（HERVs）的调节，特别是 HSV-1 可以调节参与 MS 发病机制的细胞中的 HERVs。这篇综述揭示了目前关于 HSV-1 与人类 ERVs 之间关系的知识，重点介绍了它们作为 MS 危险因素的贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef37/8199333/646a85c2033e/ijms-22-05738-g006.jpg
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