Maruyama Y, Wierzbicki J, Feola J, Urano M
Radiation Therapy Oncology Center, University of Kentucky Medical Center, Lexington 40536.
Int J Radiat Oncol Biol Phys. 1990 Jul;19(1):61-7. doi: 10.1016/0360-3016(90)90135-7.
Regeneration of clonogens in human cervical cancer was assessed by the pathological evaluation of the hysterectomy specimen after intracavitary 252Cf neutron brachytherapy implants separated by varying time intervals followed by extrafascial hysterectomy. In this study, patients with bulky/barrel shaped Stage IB cervical cancers received 252Cf implants plus approximately 45 Gy of whole pelvis linear accelerator radiotherapy in approximately 25 fractions in 5 weeks followed by hysterectomy 4-6 weeks after radiotherapy. The specimens were studied grossly and microscopically for residual tumor. It was found that the fraction of positive specimens increased with elapsed time interval between implants. These findings support the hypothesis that there is repopulation of surviving clonogens with increased time interval between the implants. The observation also supports current concerns that rapid depopulation of tumor can lead to rapid repopulation, that is, rapid shrinkage of tumor can alter the physiological environment such that clonogens can rapidly regenerate.
通过对腔内252Cf中子近距离放疗植入物以不同时间间隔分开后行筋膜外子宫切除术后的子宫切除标本进行病理评估，来评估人宫颈癌中克隆原细胞的再生情况。在本研究中，患有巨大/桶状IB期宫颈癌的患者接受252Cf植入物加约45 Gy的全盆腔直线加速器放疗，分约25次在5周内完成，放疗后4至6周行子宫切除术。对标本进行大体和显微镜下的残余肿瘤研究。发现阳性标本的比例随着植入物之间时间间隔的延长而增加。这些发现支持了这样的假设，即随着植入物之间时间间隔的增加，存活的克隆原细胞会重新增殖。该观察结果也支持了当前的担忧，即肿瘤的快速减少会导致快速再增殖，也就是说，肿瘤的快速缩小会改变生理环境，使克隆原细胞能够快速再生。
