Maruyama Y, van Nagell J R, Feola J M, Beach J L, Yoneda J, Donaldson E, Gallion H, Rowley K, Powell D
Int J Radiat Oncol Biol Phys. 1987 Oct;13(10):1473-8. doi: 10.1016/0360-3016(87)90313-0.
Using hysterectomy specimens obtained 1 month after Cf-252 neutron brachytherapy plus fractionated radiotherapy, we determined the fraction of positive and negative specimens with neutron dose for bulky Stage IB cervical cancers. The specimens obtained and studied after an initial Cf-252 insertion when the sources were newer and less decayed were more frequently negative for histological evidence of cancer than after the sources had decayed and 2 insertions were needed. After two insertions to deliver a therapeutic dose preoperatively the specimens were more frequently positive. When a larger initial dose was delivered to the tumor a larger proportion of negative specimens was noted. The size of neutron dose fraction was important to local tumor clearance and to rendering the specimens negative as well as schedule in use.
我们使用在Cf - 252中子近距离放疗加分割放疗1个月后获取的子宫切除标本，确定了大块IB期宫颈癌标本阳性和阴性的比例与中子剂量的关系。在最初插入Cf - 252且源较新、衰变较少时获取并研究的标本，与源衰变后需要进行2次插入时相比，癌症组织学证据呈阴性的情况更为常见。在术前进行2次插入以给予治疗剂量后，标本呈阳性的情况更为频繁。当向肿瘤给予更大的初始剂量时，阴性标本的比例更高。中子剂量分割的大小对局部肿瘤清除、使标本呈阴性以及使用方案都很重要。
