Department of Epidemiology and Prevention, Clinical Research Center, National Center for Global Health and Medicine, Tokyo, Japan.
Eur J Clin Nutr. 2013 Oct;67(10):1060-5. doi: 10.1038/ejcn.2013.115. Epub 2013 Jun 26.
BACKGROUND/OBJECTIVES: Vitamin B6 is suggested to have a protective role against depression. However, the association between vitamin B6 intake and depression remains inconclusive, and few studies have examined the relationship between circulating vitamin B6 concentrations and depressive symptoms. Here, we investigated the cross-sectional and prospective associations between serum pyridoxal concentrations and depressive symptoms among Japanese workers.
SUBJECTS/METHODS: Participants were 422 municipal employees (aged 21-67 years) who participated in a baseline survey in 2006 for cross-sectional analysis, and 210 subjects without depressive symptoms at baseline (2006) who completed both baseline and follow-up (2009) surveys for prospective analysis. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Logistic regression analysis was used to estimate the odds ratio of depressive symptoms (CES-D scale of ≥ 19) according to tertile of serum pyridoxal with adjustment for potential confounding variables.
In the cross-sectional analysis, serum pyridoxal concentrations were significantly associated with a decreased prevalence of depressive symptoms (P for trend=0.03); the multivariable-adjusted odds ratio of depressive symptoms for the highest tertile of pyridoxal was 0.54 (95% confidence interval 0.30-0.96) compared with the lowest tertile. In longitudinal analyses, higher serum pyridoxal concentrations at baseline were associated with a trend toward reduced depressive symptoms after 3 years; the multivariable-adjusted odds ratio of depressive symptoms for the highest versus the lowest tertile of pyridoxal concentration was 0.55 (95% confidence interval 0.13-2.32).
A higher vitamin B6 status may be associated with a decreased risk of depressive symptoms in Japanese.
背景/目的：维生素 B6 被认为对预防抑郁症有保护作用。然而，维生素 B6 摄入与抑郁症之间的关系仍不确定，并且很少有研究调查循环维生素 B6 浓度与抑郁症状之间的关系。在这里，我们研究了日本工人血清吡哆醛浓度与抑郁症状之间的横断面和前瞻性关联。
受试者/方法：参与者为 422 名市政雇员（年龄 21-67 岁），他们参加了 2006 年的基线调查进行横断面分析，而 210 名基线（2006 年）时无抑郁症状的受试者完成了基线和随访（2009 年）调查进行前瞻性分析。使用流行病学研究中心抑郁量表（CES-D 量表）评估抑郁症状。使用逻辑回归分析，根据血清吡哆醛的三分位值调整潜在混杂变量后，估计抑郁症状（CES-D 量表≥19）的比值比。
在横断面分析中，血清吡哆醛浓度与抑郁症状的患病率降低显著相关（趋势 P=0.03）；与最低三分位相比，吡哆醛最高三分位的抑郁症状的多变量调整比值比为 0.54（95%置信区间 0.30-0.96）。在纵向分析中，基线时较高的血清吡哆醛浓度与 3 年后抑郁症状减轻呈趋势相关；与吡哆醛浓度最低三分位相比，最高三分位的抑郁症状的多变量调整比值比为 0.55（95%置信区间 0.13-2.32）。
较高的维生素 B6 状态可能与日本人群中抑郁症状风险降低相关。
