朊病毒样蛋白聚集的传播与相关治疗策略。
Prion-like propagation of protein aggregation and related therapeutic strategies.
机构信息
Department of Neurology, Washington University in St Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA.
出版信息
Neurotherapeutics. 2013 Jul;10(3):371-82. doi: 10.1007/s13311-013-0196-3.
Abstract
Many neurodegenerative diseases are characterized by the progressive accumulation of aggregated protein. Recent evidence suggests the prion-like propagation of protein misfolding underlies the spread of pathology observed in these diseases. This review traces our understanding of the mechanisms that underlie this phenomenon and discusses related therapeutic strategies that derive from it.
摘要
许多神经退行性疾病的特征是蛋白质聚集体的进行性积累。最近的证据表明，蛋白质错误折叠的朊病毒样传播是这些疾病中观察到的病理扩散的基础。本文追溯了我们对这一现象背后的机制的理解，并讨论了由此产生的相关治疗策略。
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