Non-classical MHC Class I molecules regulating natural killer cell function.
作者信息
Smyth Mark J, Sullivan Lucy C, Brooks Andrew G, Andrews Daniel M
机构信息
Cancer Immunology Program; Sir Peter MacCallum Department of Oncology; University of Melbourne; Parkville, VIC Australia.
出版信息
Oncoimmunology. 2013 Mar 1;2(3):e23336. doi: 10.4161/onci.23336.
Abstract
Natural killer (NK) cells possess effector and immunoregulatory functions that are controlled by a myriad of receptor-ligand pairs, including human killer inhibitory receptor (KIR) and mouse Ly49-MHC class I interactions. We have recently shown that the NK cell inhibitory molecule Ly49A binds the non-classical MHC molecule H2-M3, thus regulating host innate immune responses to tumor initiation and metastasis.
摘要
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