双阴性（DN）[CD3⁺CD4⁻CD8⁻]T 细胞与 HIV 感染期间的疾病进展相关。

Double Negative (DN) [CD3⁺CD4⁻CD8⁻] T cells correlate with disease progression during HIV infection.

机构信息

Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.

出版信息

Immunol Invest. 2013;42(5):431-7. doi: 10.3109/08820139.2013.805763.

DOI:10.3109/08820139.2013.805763

Abstract

Although double negative T (DNT) cells (CD3⁺CD4⁻CD8⁻) share some characteristics with T regulatory cells, the relationship between DNT cells and disease progression in HIV infection is unclear. In this study, we analyzed the relationship between DNT cells and disease progression during the first 2 years of HIV infection. We found that DNT cell numbers tended to decrease with disease progression. There was a positive correlation between DNT cells and CD4 counts. The DNT cell numbers were significantly lower in the high viral load group compared with the low viral load group. Therefore, we conclude that DNT cells correlated with disease progression in HIV infection. These data provide valuable information for further understanding of the role of DNT cells during HIV infection.

摘要

虽然双阴性 T 细胞（DNT）（CD3⁺CD4⁻CD8⁻）与 T 调节细胞具有一些共同特征，但 DNT 细胞与 HIV 感染疾病进展之间的关系尚不清楚。在这项研究中，我们分析了 HIV 感染最初 2 年内 DNT 细胞与疾病进展之间的关系。我们发现，DNT 细胞数量随着疾病进展而趋于减少。DNT 细胞与 CD4 计数呈正相关。高病毒载量组的 DNT 细胞数量明显低于低病毒载量组。因此，我们得出结论，DNT 细胞与 HIV 感染中的疾病进展相关。这些数据为进一步了解 HIV 感染期间 DNT 细胞的作用提供了有价值的信息。