Madjd Zahra, Gheytanchi Elmira, Erfani Elham, Asadi-Lari Mohsen
Department of Pathology, Iran University of Medical Sciences, Tehran, Iran.
Asian Pac J Cancer Prev. 2013;14(5):2789-800. doi: 10.7314/apjcp.2013.14.5.2789.
The aim of this systematic review was to investigate whether stem cells could be effectively applied in targeted therapy of breast cancer.
A systematic literature search was performed for original articles published from January 2007 until May 2012.
Nine studies met the inclusion criteria for phase I or II clinical trials, of which three used stem cells as vehicles, two trials used autologous hematopoetic stem cells and in four trials cancer stem cells were targeted. Mesenchymal stem cells (MSCs) were applied as cellular vehicles to transfer therapeutic agents. Cell therapy with MSC can successfully target resistant cancers. Cancer stem cells were selectively targeted via a proteasome-dependent suicide gene leading to tumor regression. Wnt/β-catenin signaling pathway has been also evidenced to be an attractive CSC-target.
This systematic review focused on two different concepts of stem cells and breast cancer marking a turning point in the trials that applied stem cells as cellular vehicles for targeted delivery therapy as well as CSC-targeted therapies. Applying stem cells as targeted therapy could be an effective therapeutic approach for treatment of breast cancer in the clinic and in therapeutic marketing; however this needs to be confirmed with further clinical investigations.
本系统评价的目的是研究干细胞是否能有效应用于乳腺癌的靶向治疗。
对2007年1月至2012年5月发表的原始文章进行系统文献检索。
9项研究符合I期或II期临床试验的纳入标准，其中3项将干细胞用作载体，2项试验使用自体造血干细胞，4项试验靶向癌症干细胞。间充质干细胞（MSCs）被用作细胞载体来转运治疗药物。用MSCs进行细胞治疗可成功靶向耐药癌症。通过蛋白酶体依赖性自杀基因选择性靶向癌症干细胞可导致肿瘤消退。Wnt/β-连环蛋白信号通路也已被证明是一个有吸引力的癌症干细胞靶点。
本系统评价聚焦于干细胞与乳腺癌的两种不同概念，这标志着在将干细胞用作细胞载体进行靶向递送治疗以及癌症干细胞靶向治疗的试验中出现了一个转折点。将干细胞用作靶向治疗可能是临床上和治疗市场上治疗乳腺癌的一种有效治疗方法；然而，这需要进一步的临床研究来证实。
