Qin Qi, Xu Xin, Wang Xiao, Zheng Xiang-Yi
Department of General Surgery, Childrens Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Asian Pac J Cancer Prev. 2013;14(5):3117-21. doi: 10.7314/apjcp.2013.14.5.3117.
Previous epidemiologic studies demonstrated that obesity might associated with the risk of bladder cancer. However, many of the actual association findings remained conflicting. To better clarify and provide a comprehensive summary of the correlation between obesity and bladder cancer risk, we conducted a meta-analysis to summarize results of studies on the issue. Stratified analyses were also performed on potential variables and characteristics.
Studies were identified by searching in PubMed and Wanfang databases, covering all the papers published from their inception to March 10, 2013. Summary relative risks (SRRs) with their corresponding 95% confidence intervals (CIs) were calculated by either random-effect or fixed-effect models.
A total of 11 cohort studies were included in our meta-analysis, which showed that obesity was associated with an increased risk for bladder cancer in all subjects (RR=1.10, 95% CI=1.06-1.16; p=0.215 for heterogeneity; I2=24.0%). Among the 9 studies that controlled for cigarette smoking, the pooled RR was 1.09 (95% CI 1.01-1.17; p=0.131 for heterogeneity; I2=35.9%). No significant publication bias was detected (p = 0.244 for Egger's regression asymmetry test).
Our results support the conclusion that obesity is associated with the increased risk of bladder cancer. Further research is needed to generate a better understanding of the correlation and to provide more convincing evidence for clinical intervention in the prevention of bladder cancer.
既往流行病学研究表明，肥胖可能与膀胱癌风险相关。然而，许多实际的关联研究结果仍相互矛盾。为了更好地阐明并全面总结肥胖与膀胱癌风险之间的相关性，我们进行了一项荟萃分析以总结该问题的研究结果。还对潜在变量和特征进行了分层分析。
通过检索PubMed和万方数据库来识别研究，涵盖从建库至2013年3月10日发表的所有论文。采用随机效应模型或固定效应模型计算汇总相对风险（SRR）及其相应的95%置信区间（CI）。
我们的荟萃分析共纳入11项队列研究，结果显示肥胖与所有受试者患膀胱癌风险增加相关（RR = 1.10，95%CI = 1.06 - 1.16；异质性p = 0.215；I² = 24.0%）。在9项控制了吸烟因素的研究中，合并RR为1.09（95%CI 1.01 - 1.17；异质性p = 0.131；I² = 35.9%）。未检测到显著的发表偏倚（Egger回归不对称检验p = 0.244）。
我们的结果支持肥胖与膀胱癌风险增加相关这一结论。需要进一步研究以更好地理解这种相关性，并为预防膀胱癌的临床干预提供更有说服力的证据。
