Hang Wei, Sun Shijun, Ye Yijing, Fang Weiyi
Cancer Research Institute, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2013 Jun;33(6):882-4.
To evaluate the correlation of p27 protein expression in the cytoplasm with the clinicopathologic features of nasopharyngeal carcinoma (NPC).
Immunohistochemistry was employed to examine P27 protein expression in the cytoplasm of NPC samples and nasopharyngeal (NP) tissue samples. The differential expression of P27 protein between NPCs and NPs and the correlation of cytoplasmic P27 protein expression with the clinicopathologic parameters of NPC patients was analyzed. RESULTS Immunohistochemistry indicated significantly down-regulated t p27 protein expression in NPC tissues compared to that in NP tissues (P=0.047). The reduction of P27 expression was inversely correlated with T classification of NPC (P=0.033). Although cytoplasmic p27 protein expression was not significantly correlated with lymph node metastasis (P=0.157) or clinical stages of NPC (P=0.090), an obvious trend of inverse correlations between them was noted.
Down-regulated cytoplasmic p27 protein expression may promote the carcinogenesis of NPC and can be an unfavorable prognostic factor for survival of NPC patients.
评估细胞质中p27蛋白表达与鼻咽癌（NPC）临床病理特征的相关性。
采用免疫组织化学法检测NPC样本和鼻咽（NP）组织样本细胞质中P27蛋白的表达。分析NPC与NP之间P27蛋白的差异表达以及细胞质P27蛋白表达与NPC患者临床病理参数的相关性。结果免疫组织化学显示，与NP组织相比，NPC组织中t p27蛋白表达显著下调（P = 0.047）。P27表达的降低与NPC的T分级呈负相关（P = 0.033）。虽然细胞质p27蛋白表达与淋巴结转移（P = 0.157）或NPC的临床分期（P = 0.090）无显著相关性，但注意到它们之间存在明显的负相关趋势。
细胞质p27蛋白表达下调可能促进NPC的发生，并且可能是NPC患者生存的不良预后因素。
