伴侣蛋白介导的蛋白质折叠。
Chaperonin-mediated protein folding.
机构信息
Howard Hughes Medical Institute, Yale School of Medicine, New Haven, Connecticut 06510, USA.
出版信息
J Biol Chem. 2013 Aug 16;288(33):23622-32. doi: 10.1074/jbc.X113.497321. Epub 2013 Jun 26.
Abstract
We have been studying chaperonins these past twenty years through an initial discovery of an action in protein folding, analysis of structure, and elucidation of mechanism. Some of the highlights of these studies were presented recently upon sharing the honor of the 2013 Herbert Tabor Award with my early collaborator, Ulrich Hartl, at the annual meeting of the American Society for Biochemistry and Molecular Biology in Boston. Here, some of the major findings are recounted, particularly recognizing my collaborators, describing how I met them and how our great times together propelled our thinking and experiments.
摘要
在过去的二十年里，我们通过最初对蛋白质折叠作用的发现、结构分析和机制阐明，一直在研究分子伴侣。最近，我与早期的合作者 Ulrich Hartl 在波士顿举行的美国生物化学与分子生物学学会年会上共同分享了 2013 年赫伯特·塔博奖（Herbert Tabor Award），我们介绍了这些研究的部分重点内容。本文讲述了一些主要发现，特别感谢我的合作者，描述了我是如何与他们相识的，以及我们一起度过的美好时光如何推动了我们的思考和实验。
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