正常的维生素D水平与乙肝表面抗原自然血清清除有关。
Normal vitamin D levels are associated with spontaneous hepatitis B surface antigen seroclearance.
作者信息
Mahamid Mahmud, Nseir William, Abu Elhija Omar, Shteingart Shimon, Mahamid Ammad, Smamra Mosab, Koslowsky Benjamin
机构信息
Mahmud Mahamid, Shimon Shteingart, Mosab Smamra, Benjamin Koslowsky, Digestive Disease Institute, Shaare Zedek Medical Center, Jerusalem 93722, Israel.
出版信息
World J Hepatol. 2013 Jun 27;5(6):328-31. doi: 10.4254/wjh.v5.i6.328.
AIM
To investigate a possible association between serum vitamin D levels and spontaneous hepatitis B surface antigen (HBsAg) seroclearance.
METHODS
Fifty-three patients diagnosed with chronic inactive hepatitis B and spontaneous HBsAg seroclearance were followed up in two Israeli liver units between 2007 and 2012. This retrospective study reviewed medical charts of all the patients, extracting demographic, serological and vitamin D rates in the serum, as well as medical conditions and current medical therapy. Spontaneous HBsAg seroclearance was defined as the loss of serum HBsAg indefinitely. Vitamin D levels were compared to all patients who underwent spontaneous HBsAg seroclearance.
RESULTS
Out of the 53 patients who underwent hepatitis B antigen seroclearance, 44 patients (83%) had normal levels of 25-hydroxyvitamin vitamin D compared to 9 patients (17%) who had below normal levels. Multivariate analysis showed that age (> 35 years) OR = 1.7 (95%CI: 1.25-2.8, P = 0.05), serum vitamin D levels (> 20 ng/mL) OR = 2.6 (95%CI: 2.4-3.2, P = 0.02), hepatitis B e antigen negativity OR = 2.1 (95%CI: 2.2-3.1, P = 0.02), low viral load (hepatitis B virus DNA < 100 IU/mL) OR = 3 (95%CI: 2.6-4.2, P = 0.01) and duration of HBsAg seropositivity (> 8 years) OR = 1.6 (95%CI: 1.15-2.6, P = 0.04) were also associated with spontaneous HBsAg seroclearance.
CONCLUSION
We found a strong correlation between normal vitamin D levels and spontaneous HBsAg seroclearance.
目的
研究血清维生素D水平与自发性乙肝表面抗原（HBsAg）血清学清除之间的可能关联。
方法
2007年至2012年期间，在以色列的两个肝病治疗中心对53例诊断为慢性非活动性乙型肝炎且出现自发性HBsAg血清学清除的患者进行了随访。这项回顾性研究查阅了所有患者的病历，提取了人口统计学、血清学和血清维生素D水平，以及医疗状况和当前的治疗方法。自发性HBsAg血清学清除定义为血清HBsAg持续消失。将维生素D水平与所有发生自发性HBsAg血清学清除的患者进行比较。
结果
在53例经历乙肝抗原血清学清除的患者中，44例（83%）25-羟维生素D水平正常，9例（17%）低于正常水平。多因素分析显示，年龄（>35岁）比值比（OR）=1.7（95%置信区间：1.25-2.8，P=0.05），血清维生素D水平（>20 ng/mL）OR=2.6（95%置信区间：2.4-3.2，P=0.02），乙肝e抗原阴性OR=2.1（95%置信区间：2.2-3.1，P=0.02），低病毒载量（乙肝病毒DNA<100 IU/mL）OR=3（95%置信区间：2.6-4.2，P=0.01）以及HBsAg血清学阳性持续时间（>8年）OR=1.6（95%置信区间：1.15-2.6，P=0.04）也与自发性HBsAg血清学清除相关。
结论
我们发现维生素D水平正常与自发性HBsAg血清学清除之间存在密切关联。
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