Nano Technology Research Unit, Department of Chemistry, Faculty of Science, Mahasarakham University and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Khamriang, Kantarawichai, Maha Sarakham, 44150, Thailand.
J Nat Prod. 2013 Jul 26;76(7):1358-64. doi: 10.1021/np400268d. Epub 2013 Jun 27.
Eight new compounds, fimbricalyxs B-D (1-3), fimbricalyxanhydrides A and B (4, 5), and fimbricalyxlactones A-C (6-8), together with three known compounds, trigonostemone (9), 3,6,9-trimethoxyphenanthropolone (10), and fimbricalyx A (11), were isolated from the roots of Strophioblachia fimbricalyx. The structures of the new compounds were elucidated on the basis of their spectroscopic data and, in the case of compounds 2, 4, and 7, confirmed by single-crystal X-ray crystallographic analysis. Compounds 1-4 and 8 were evaluated for their cytotoxicity (KB, MCF7, and NCI-H187 cancer cells) and antiplasmodial activity (Plasmodium falciparum, K1 multidrug-resistant strain). Fimbricalyx B (1) exhibited potent antiplasmodial activity with an IC50 value of 0.019 μM, while 4 was cytotoxic toward NCI-H187 cancer cells and showed antiplasmodial activities with IC50 values of 5.7 and 3.9 μM, respectively. In addition, the X-ray structure of 10 and the antiplasmodial activity of 11 are reported herein for the first time.
从细梗胡枝子的根部分离得到了 8 个新化合物，即 fimbricalyxs B-D（1-3）、fimbricalyxanhydrides A 和 B（4,5）以及 fimbricalyxlactones A-C（6-8），以及 3 个已知化合物，即 trigonostemone（9）、3,6,9-三甲氧基菲诺酮（10）和 fimbricalyx A（11）。新化合物的结构是根据其光谱数据确定的，对于化合物 2、4 和 7，还通过单晶 X 射线晶体学分析进行了确证。对化合物 1-4 和 8 进行了细胞毒性（KB、MCF7 和 NCI-H187 癌细胞）和抗疟原虫活性（疟原虫 falciparum，K1 多药耐药株）评估。化合物 1 表现出很强的抗疟原虫活性，IC50 值为 0.019 μM，而化合物 4 对 NCI-H187 癌细胞具有细胞毒性，并表现出分别为 5.7 和 3.9 μM 的抗疟原虫活性。此外，本文首次报道了化合物 10 的 X 射线结构和化合物 11 的抗疟原虫活性。
