Molecular Tracer LLC, Bethesda, MD 20814, USA.
Drug Discov Today. 2013 Oct;18(19-20):984-91. doi: 10.1016/j.drudis.2013.06.008. Epub 2013 Jun 24.
Technetium-99m (Tc-99m) has long been a mainstay in clinical nuclear medicine, primarily monitoring biological processes in the heart, kidney, liver, and brain. More recently, Tc-99m chelates have been used as the reporter in targeted nuclear medicine probes that monitor changes in specific protein expression products. The strengths remain the inexpensive source of Tc-99m from the Mo-99/Tc-99m generator, its rich chemistry, high-yield kit formulation, and its widespread availability. Hardware and software advances, such as OSEM reconstructions with scatter and attenuation corrections, have led to quantitation of the injected radioactivity in terms of kBq/cm.
锝-99m（Tc-99m）长期以来一直是临床核医学的主要手段，主要用于监测心脏、肾脏、肝脏和大脑中的生物过程。最近，Tc-99m 螯合物已被用作靶向核医学探针中的报告物，以监测特定蛋白质表达产物的变化。其优势仍然是从钼-99/锝-99m 发生器中获得 Tc-99m 的廉价来源、丰富的化学性质、高产量试剂盒配方以及广泛的可用性。硬件和软件的进步，如带有散射和衰减校正的 OSEM 重建，已经能够定量注射放射性活度，以 kBq/cm 为单位。
