Eyre J A, Flecknell P A, Kenyon B R, Koh T H, Miller S
Department of Child Health, University of Newcastle upon Tyne, United Kingdom.
J Neurol Neurosurg Psychiatry. 1990 Jun;53(6):507-13. doi: 10.1136/jnnp.53.6.507.
The influence of repeated high intensity electromagnetic stimulation of the brain on cortical activity, cortical blood flow, blood pressure and heart rate has been investigated in the cat, to evaluate the safety of the method. The observations have been made in preparations under propofol anaesthesia before, during and after periods of anoxia. Electromagnetic stimulation of the brain evoked activity in descending motor pathways and was recorded by activity in the median nerve and by muscle twitches. Following repeated series of high intensity stimulation there were no systematic changes in somatosensory evoked potentials or background EEG, nor were there signs of epileptogenic activity during electromagnetic stimulation, before, during or after periods of anoxia. No systematic changes in cortical blood flow, blood pressure or heart rate were observed during electromagnetic stimulation, before or after periods of anoxia. In conclusion, no acute adverse consequences following electromagnetic stimulation in the normal and anoxic cat brain were demonstrated.
为评估重复高强度脑电磁刺激方法的安全性，已在猫身上研究了其对皮质活动、皮质血流量、血压和心率的影响。观察是在丙泊酚麻醉下的实验准备中，于缺氧期之前、期间和之后进行的。脑电磁刺激诱发下行运动通路的活动，并通过正中神经的活动和肌肉抽搐进行记录。在重复进行一系列高强度刺激后，体感诱发电位或背景脑电图没有系统性变化，在缺氧期之前、期间或之后的电磁刺激过程中也没有致痫活动的迹象。在电磁刺激期间、缺氧期之前或之后，未观察到皮质血流量、血压或心率的系统性变化。总之，未证明正常和缺氧猫脑在电磁刺激后有急性不良后果。
