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一名年轻男性肾动脉纤维肌性发育异常伴双侧肾梗死

Fibromuscular dysplasia of renal arteries presenting with bilateral renal infarction in a young man.

作者信息

Basile Carlo, Lisi Piero, Chimienti Domenico, Antonelli Maurizio, Bruno Andrea, Giambersio Silvia, Zurlo Maria Teresa, Petronelli Sergio

机构信息

Nephrology and Dialysis Unit, Miulli General Hospital, Acquaviva delle Fonti - Italy.

出版信息

J Nephrol. 2013 Sep-Oct;26(5):945-8. doi: 10.5301/jn.5000257. Epub 2013 Jun 14.

Abstract

Fibromuscular dysplasia (FMD) describes a group of conditions which cause nonatheromatous arterial stenoses, most commonly of the renal and carotid arteries, typically in young women. We report the case of a previously healthy 43-year-old white man presenting with acute bilateral flank pain. The pain was more severe on the left side. Initially treated for ureteral colic, he was transferred to the nephrology unit upon recognition of a rising serum creatinine. He was found to have FMD of bilateral renal arteries with resultant infarctions in both kidneys. He was treated with intravenous heparin and, then, warfarin at discharge. At a 16-month review, the patient remained pain-free with normal renal function and with antiplatelet and dual antihypertensive therapy. In conclusion, renal infarction complicating FMD is rare, with most cases involving causative cardiovascular risk factors, including coagulopathy, ischemic heart disease, atrial fibrillation or structural cardiac abnormalities, none of which was present in this case. What makes this case interesting are the clinically significant bilateral renal infarctions due to atypical asymmetric FMD in both kidneys in a young man.

摘要

纤维肌发育异常(FMD)是指一组导致非动脉粥样硬化性动脉狭窄的病症,最常见于肾动脉和颈动脉,多见于年轻女性。我们报告一例既往健康的43岁白人男性,因急性双侧胁腹疼痛就诊。左侧疼痛更为严重。最初按输尿管绞痛治疗,在发现血清肌酐升高后转至肾病科。检查发现他双侧肾动脉存在纤维肌发育异常,双肾均出现梗死。给予静脉注射肝素治疗,出院时改为华法林治疗。在16个月的复查中,患者无疼痛,肾功能正常,接受抗血小板和双重降压治疗。总之,纤维肌发育异常并发肾梗死很罕见,大多数病例伴有心血管危险因素,包括凝血病、缺血性心脏病、心房颤动或心脏结构异常,本病例均无这些情况。该病例的有趣之处在于,一名年轻男性因双侧肾脏非典型不对称纤维肌发育异常导致临床上显著的双侧肾梗死。

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