Tian Feng, Xu Feng, Zhang Zheng-Yu, Ge Jing-Ping, Wei Zhi-Feng, Xu Xiao-Feng, Cheng Wen
Department of Urology, Jinling Hospital, No. 305, Zhongshandong Road, Nanjing, 210002, China.
Tumour Biol. 2013 Dec;34(6):3687-90. doi: 10.1007/s13277-013-0951-4. Epub 2013 Jun 27.
Chromodomain helicase/ATPase DNA-binding protein 1-like (CHD1L) is overexpressed and highly associated with poor prognosis in many malignancies. However, the role of CHD1L in bladder cancer (BC) has not been thoroughly elucidated. The aim of this study is to investigate the relationship of CHD1L expression with clinicopathological parameters and prognosis in BC. Immunohistochemistry was carried out to investigate the protein expression of CHD1L in 153 BC tissues and 87 adjacent noncancerous tissues. Our data found that CHD1L protein expression was significantly higher in BC tissues than in adjacent noncancerous tissues (P < 0.001). CHD1L overexpression was significantly correlated with histologic grade (P = 0.005) and tumor stage (P = 0.009). The Kaplan-Meier survival analysis revealed that survival time of patients with high CHD1L expression was significantly shorter than that with low CHD1L expression. Multivariate analysis further demonstrated that CHD1L was an independent prognostic factor for patients with BC. In conclusion, CHD1L is likely to be a valuable marker for carcinogenesis and progression of BC. It might be used as an important diagnostic and prognostic marker for BC patients.
染色质结构域解旋酶/ATP酶DNA结合蛋白1样蛋白（CHD1L）在许多恶性肿瘤中过度表达，且与预后不良高度相关。然而，CHD1L在膀胱癌（BC）中的作用尚未得到充分阐明。本研究旨在探讨CHD1L表达与BC临床病理参数及预后的关系。采用免疫组织化学法检测153例BC组织和87例癌旁非癌组织中CHD1L的蛋白表达。我们的数据发现，BC组织中CHD1L蛋白表达显著高于癌旁非癌组织（P < 0.001）。CHD1L过表达与组织学分级（P = 0.005）和肿瘤分期（P = 0.009）显著相关。Kaplan-Meier生存分析显示，CHD1L高表达患者的生存时间显著短于CHD1L低表达患者。多因素分析进一步表明，CHD1L是BC患者的独立预后因素。总之，CHD1L可能是BC发生和进展的一个有价值的标志物。它可能用作BC患者重要的诊断和预后标志物。
