Huu Alice Le, Paul Arghya, Prakash Satya, Shum-Tim Dominique
Division of Cardiac Surgery, Department of Surgery, McGill University Health Center, McGill University, Montreal, QC, Canada.
Methods Mol Biol. 2013;1036:121-35. doi: 10.1007/978-1-62703-511-8_11.
Stem cell transplantation has been considered as a major breakthrough for treating ischemic heart disease. However, survival and retention of transplanted cells at the site of infarction remains tenuous. This chapter details a method of creating polymeric microcapsules for cell delivery, resulting in increased retention of transplanted cells at the target site, while achieving minimal mechanical trauma and cell loss. Simultaneously biocompatible and biodegradable, polymeric microcapsules have important implications in regenerative cell therapy.
干细胞移植已被视为治疗缺血性心脏病的一项重大突破。然而，移植细胞在梗死部位的存活和留存情况仍然不佳。本章详细介绍了一种制备用于细胞递送的聚合物微胶囊的方法，该方法可提高移植细胞在靶位点的留存率，同时使机械损伤和细胞损失降至最低。聚合物微胶囊具有生物相容性和可生物降解性，在再生细胞治疗中具有重要意义。
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