Kochanowski B A
Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, OH 45239.
J Nutr. 1990 Aug;120(8):876-81. doi: 10.1093/jn/120.8.876.
It has been previously demonstrated that calcium from calcium citrate-malate (CCM), a mixture of calcium, citric acid and malic acid, is better-absorbed than calcium from calcium carbonate (CaCO3) in humans and in rats. It was of interest to determine if this differential in absorption would result in differences in bone development under chronic feeding conditions. The present study was designed to compare CCM with CaCO3 for effects on bone development in weanling female C/D rats fed either CCM or CaCO3 at 0.3 or 0.6% dietary Ca for 4 or 12 wk. There was a nonsignificant trend for rats fed CCM to weigh more and have larger bones than rats fed CaCO3. Histologic evaluation of cortical and trabecular bone revealed normal bone formation in all rats. Trabecular bone was significantly affected by calcium level and source. The 0.3% Ca diets (either source) resulted in reduced trabecular bone volumes in tibias. After 4 wk, rats fed CCM had 23-25% more trabecular bone than rats fed CaCO3. By 12 wk, the difference was even greater; rats fed CCM had 44-47% more trabecular bone than rats fed CaCO3. Dietary calcium source did not affect cortical bone. It is concluded that because of its positive effects on bone, CCM is a more bioavailable calcium source than CaCO3.
先前已有研究表明，柠檬酸苹果酸钙（CCM，一种钙、柠檬酸和苹果酸的混合物）中的钙在人体和大鼠体内的吸收效果优于碳酸钙（CaCO₃）中的钙。本研究旨在确定这种吸收差异在长期喂食条件下是否会导致骨骼发育出现差异。本研究旨在比较CCM和CaCO₃对断奶雌性C/D大鼠骨骼发育的影响，这些大鼠分别以0.3%或0.6%的膳食钙摄入CCM或CaCO₃，持续4周或12周。喂食CCM的大鼠比喂食CaCO₃的大鼠体重更重、骨骼更大，但差异不显著。对皮质骨和小梁骨的组织学评估显示，所有大鼠的骨形成均正常。小梁骨受钙水平和来源的影响显著。0.3%钙的饮食（任何一种来源）都会导致胫骨小梁骨体积减少。4周后，喂食CCM的大鼠小梁骨比喂食CaCO₃的大鼠多23% - 25%。到12周时，差异更大；喂食CCM的大鼠小梁骨比喂食CaCO₃的大鼠多44% - 47%。膳食钙来源不影响皮质骨。研究得出结论，由于CCM对骨骼有积极作用，因此它是一种比CaCO₃生物利用度更高的钙源。
