Smith K T, Heaney R P, Flora L, Hinders S M
Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio.
Calcif Tissue Int. 1987 Dec;41(6):351-2. doi: 10.1007/BF02556676.
Absorption of calcium from a highly soluble form of calcium, a mixed calcium citrate-malate salt (CCM), was tested against calcium carbonate and milk in both rats and humans. The rat method estimated absorption from the 6-day retention of an oral tracer, and the human method employed the standard double-isotope procedure. CCM was given both as a dry powder and in an orange juice beverage. In two experiments in rats calcium from CCM was absorbed at least as well as, if not better than from calcium carbonate or milk. In two separate experiments in humans, calcium from CCM was absorbed significantly better than from calcium carbonate or milk. We conclude that CCM exhibits excellent bioavailability and that this formulation is a useful addition to the forms of calcium now available either for direct supplementation or for food fortification.
针对碳酸钙和牛奶，在大鼠和人类身上测试了一种高溶解性钙——柠檬酸苹果酸钙混合盐（CCM）的钙吸收情况。大鼠实验方法通过口服示踪剂6天的留存率来估算吸收情况，人类实验方法采用标准双同位素程序。CCM既以干粉形式给药，也制成橙汁饮料给药。在大鼠的两项实验中，CCM中的钙吸收效果至少与碳酸钙或牛奶相当，甚至可能更好。在人类的两项独立实验中，CCM中的钙吸收显著优于碳酸钙或牛奶。我们得出结论，CCM具有极佳的生物利用度，这种制剂是目前可用于直接补充或食品强化的钙形式的有益补充。
