Zybaĭlov B L, Sherpa M D, Glazko G V, Raney K D, Glazko V I
Mol Biol (Mosk). 2013 Mar-Apr;47(2):224-31. doi: 10.7868/s0026898413020183.
A comparative analysis in silico of distribution of nucleotide sequences that predispose to formation of non-canonical DNA structure of G-quadruplexes, closely related with gene expression regulation and double strand DNA breaks, within vertebrata and yeast nuclear and mitochondrial genomes was carried out. Data on preferable localization of potential quadruplexes within non-coding sequences, their evolutionary conservation, and existing homology between them in mitochondrial and nuclear genomes were obtained. A possible interrelation between quadruplexes, Pif1 helicase and genomic instability is discussed.
对脊椎动物和酵母的核基因组与线粒体基因组中，与基因表达调控及双链DNA断裂密切相关的、易于形成非经典G-四链体DNA结构的核苷酸序列分布进行了计算机模拟比较分析。获得了关于潜在四链体在非编码序列中的优先定位、其进化保守性以及线粒体和核基因组之间现存同源性的数据。讨论了四链体、Pif1解旋酶与基因组不稳定性之间可能的相互关系。
