Alberici Pastore Carla, Paiva Orlandi Silvana, González María Cristina
Post-graduation Program on Health and Behaviour, Catholic University of Pelotas, RS, Brazil.
Nutr Hosp. 2013 Jan-Feb;28(1):188-93. doi: 10.3305/nh.2013.28.1.6167.
Cachexia is a multifatorial syndrome characterized by loss of body weight, fat and muscle, increasing morbidity and mortality. The use of an index accounting for both serum albumin and C Reactive Protein levels could make early identification of cachexia easier.
To evaluate the variation of an inflammatory nutritional index related to nutritional status in cancer patients.
Cross sectional study including patients with gastrointestinal and lung cancer of a public chemotherapy service in Brazil. Serum albumin and C Reactive Protein were measured and the nutritional status was defined by Subjective Global Assessment. Statistical analyses were performed using Stata 9.2(TM).
A total of 74 patients were evaluated, 58.1% of them were male, mean age 63.4 ± 11.9 years old. Gastrointestinal cancer was the most prevalent type (71.6%). Only 13.7% of the patients were well nourished and 21.9% were severely malnourished. C Reactive Protein significantly increased according to nutritional status decline (p=0.03). When the albumin from patients with systemic inflammation was evaluated, there was no significant variation in relation to nutritional status (p=0.06). The Inflammatory Nutritional Index significantly varied in relation to nutritional status independent of the systemic inflammation (p=0.02).
Inflammatory Nutritional Index can be an adjuvant way for biochemical nutritional assessment and follow up in cancer patients with systemic inflammation.
恶病质是一种多因素综合征，其特征为体重、脂肪和肌肉丢失，发病率和死亡率增加。使用一个综合血清白蛋白和C反应蛋白水平的指标可能会使恶病质的早期识别更加容易。
评估一种与癌症患者营养状况相关的炎症营养指标的变化。
横断面研究，纳入巴西一家公共化疗服务机构中患有胃肠道癌和肺癌的患者。检测血清白蛋白和C反应蛋白，并通过主观全面评定法确定营养状况。使用Stata 9.2(TM)进行统计分析。
共评估了74例患者，其中58.1%为男性，平均年龄63.4±11.9岁。胃肠道癌是最常见的类型(71.6%)。只有13.7%的患者营养状况良好，21.9%的患者严重营养不良。C反应蛋白随着营养状况下降而显著升高(p=0.03)。当评估全身性炎症患者的白蛋白时，其与营养状况无显著差异(p=0.06)。炎症营养指标与营养状况显著相关，且不受全身性炎症影响(p=0.02)。
炎症营养指标可作为对伴有全身性炎症的癌症患者进行生化营养评估和随访的辅助方法。
