Department of Pathology, Division of Medical Screening and Special Testing, Women & Infants Hospital and the Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA.
Arch Pathol Lab Med. 2013 Jul;137(7):921-6. doi: 10.5858/arpa.2012-0319-CP.
Participants in a College of American Pathologists external proficiency testing program for first and second trimester Down syndrome screening.
To determine the number of women screened for Down syndrome in the United States, along with the type of test received and to compare those results to earlier surveys in 1988 and 1992.
Questionnaires regarding the type and number of Down syndrome tests performed per month were completed by participants in early 2011 and again in early 2012.
After accounting for some of the missing responses, data from up to 131 laboratories indicated that 67% (2 764 020 of 4 130 000) to 72% (2012: 2 963 592 of 4 130 000) of US pregnancies received prenatal screening for Down syndrome. Second trimester tests were most common (2012: 60%; 1 770 024 of 2 963 592), followed by integrated (2012: 21%; 627 876 of 2 963 592), and first trimester (2012: 19%; 565 692 of 2 963 592). The 6 largest laboratories tested 61% of screened pregnancies and offered the widest array of tests, while the smallest 32 tested 1% and almost always offered only second trimester tests.
The current population estimate of 72% pregnancies screened annually is higher than estimates from 1988 (25%) and 1992 (50%). Available testing choices are also more varied, and all testing methods perform better than those methods available 10 years ago. Clinicians should ensure that women are offered tests that follow recommended best-practice testing protocols, and screening laboratories should assess whether patient needs are being met.
参与者在一个美国病理学家学会（College of American Pathologists）的第一和第二孕期唐氏综合征筛查外部能力验证计划中。
确定美国进行唐氏综合征筛查的妇女人数，以及她们所接受的检查类型，并与 1988 年和 1992 年的早期调查结果进行比较。
参与者在 2011 年初和 2012 年初完成了关于每月进行的唐氏综合征检查类型和数量的问卷。
在考虑了一些缺失的回复后，来自多达 131 个实验室的数据表明，67%（2012 年：413 万中的 276.402 万）至 72%（2012 年：413 万中的 296.359 万）的美国孕妇接受了唐氏综合征的产前筛查。第二个三个月的检查最为常见（2012 年：60%；296.359 万中的 177.024 万），其次是综合检查（2012 年：21%；296.359 万中的 62.7876 万），以及第一个三个月的检查（2012 年：19%；296.359 万中的 56.5692 万）。最大的 6 个实验室检测了 61%的筛查孕妇，并提供了最广泛的检查，而最小的 32 个实验室检测了 1%，几乎总是只提供第二个三个月的检查。
目前每年筛查的孕妇比例估计为 72%，高于 1988 年（25%）和 1992 年（50%）的估计。现有的检测选择也更加多样化，所有的检测方法都比 10 年前的方法表现得更好。临床医生应该确保为妇女提供符合最佳实践检测方案的检查，而筛查实验室应评估是否满足了患者的需求。
