Onishi T, Ueda K, Horie M, Kajikawa T, Ohishi I
College of Agriculture, University of Osaka Prefecture, Japan.
J Parasitol. 1990 Aug;76(4):564-7.
The hemolytic activity in serum of Babesia gibsoni-infected dogs was examined. When the activity was assayed in a reaction system consisting of similar concentrations of the serum and canine red blood cells to those in blood, significant hemolysis was observed. The activity of the serum of B. gibsoni-infected dogs, either naturally or experimentally, was always higher than that of uninfected animals. Moreover, in the experimental infection with B. gibsoni, the change in serum hemolytic activity was parallel to those of anemia and parasitemia, whereas it was inversely parallel to that of the hematocrit value. The present study revealed the presence of a hemolytic factor(s) in the serum of B. gibsoni-infected dogs, suggesting that the progressive anemia was due to hemolysis by the factor(s).
检测了感染吉氏巴贝斯虫犬血清中的溶血活性。当在一个由与血液中浓度相似的血清和犬红细胞组成的反应体系中检测该活性时，观察到显著溶血现象。自然感染或实验感染吉氏巴贝斯虫犬的血清活性总是高于未感染动物。此外，在吉氏巴贝斯虫实验感染中，血清溶血活性的变化与贫血和寄生虫血症的变化平行，而与血细胞比容值的变化呈反平行。本研究揭示了感染吉氏巴贝斯虫犬血清中存在溶血因子，提示进行性贫血是由该因子导致的溶血所致。
