Vaccine Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Immunity. 2013 Jun 27;38(6):1083-5. doi: 10.1016/j.immuni.2013.06.008.
To understand the adaptations of costimulatory molecules through mammalian evolution, Forni et al. (Forni et al., 2013) studied evolutionary selection in key costimulatory genes. Their results, presented in this issue of Immunity, suggest that the risk of autoimmmunity is balanced against efficacy of the anti-pathogen immune response.
为了了解共刺激分子在哺乳动物进化过程中的适应性，Forni 等人（Forni 等人，2013 年）研究了关键共刺激基因中的进化选择。他们的研究结果发表在本期《免疫》杂志上，表明自身免疫的风险与抗病原体免疫反应的效果之间存在平衡。
