钾离子下降会使 NLRP3 炎症小体发生倾斜。
K⁺ drops tilt the NLRP3 inflammasome.
机构信息
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
出版信息
Immunity. 2013 Jun 27;38(6):1085-8. doi: 10.1016/j.immuni.2013.06.001.
PMID:23809157
Abstract
Unwarranted NLRP3 activation causes inflammatory disease. Its activation must therefore be specifically licensed. In this issue of Immunity, Munoz-Planillo et al. (2013) reveal K⁺ efflux as the sole common denominator of an array of unrelated stimuli engaging this inflammasome.
摘要
NLRP3 的过度激活会导致炎症性疾病，因此必须对其激活进行特异性调控。在本期《免疫》杂志中，Munoz-Planillo 等人（2013）揭示了钾离子外流是激活该炎症小体的一系列不相关刺激物的唯一共同特征。
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