Weber Steven S, Annenberg Alan J, Wright Creighton B, Braverman Timothy S, Mesh Charles L
Department of Surgery, Mercy Jewish Hospital, Cincinnati, Ohio.
Cardiac, Vascular, and Thoracic Surgeons, Inc, Cincinnati, Ohio.
J Vasc Surg. 2014 Apr;59(4):1116-8. doi: 10.1016/j.jvs.2013.05.012. Epub 2013 Jul 1.
A newly-approved carotid patch, derived from porcine small intestinal submucosa (SIS), is thought to allow functional tissue regeneration by acting as a biologic scaffold of extracellular matrix. We report three cases of asymptomatic pseudoaneurysm after SIS patch closure. At exploration there were intact suture lines, no growth from cultures, and central patch herniation. Histopathologic examination showed postendarterectomy neointima in the artery and disorganized collagen in the pseudoaneurysm. SIS patch remnants adjacent to macrophage infiltration and neovascularization indicated ongoing processes of degradation and synthesis. Imbalances between degradation and host tissue synthesis are problems that may unpredictably affect SIS patch integrity.
一种新获批的颈动脉补片，源自猪小肠黏膜下层（SIS），被认为可通过充当细胞外基质的生物支架来实现功能性组织再生。我们报告了3例SIS补片修补术后无症状假性动脉瘤的病例。术中探查发现缝合线完整，培养物无生长，且补片中央疝出。组织病理学检查显示动脉内膜切除术后动脉内有新生内膜，假性动脉瘤内胶原排列紊乱。与巨噬细胞浸润和新生血管形成相邻的SIS补片残余物表明存在持续的降解和合成过程。降解与宿主组织合成之间的失衡是可能不可预测地影响SIS补片完整性的问题。
