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理解细胞外基质以增强基于干细胞的组织再生。

Understanding the Extracellular Matrix to Enhance Stem Cell-Based Tissue Regeneration.

机构信息

Departments of Anesthesiology and Biomedical Engineering, Yale University, New Haven, CT 06520, USA.

出版信息

Cell Stem Cell. 2018 Mar 1;22(3):302-305. doi: 10.1016/j.stem.2018.02.001.

DOI:10.1016/j.stem.2018.02.001
PMID:29499149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5937845/
Abstract

The extracellular matrix is a biologically critical entity that has historically been poorly understood. Here we discuss how new tools for characterizing matrix composition and function enable us to design and deliver advanced matrices in vitro, to optimize regeneration, and in vivo, within a variety of tissues and organs.

摘要

细胞外基质是一种具有重要生物学意义的物质,但长期以来人们对其了解甚少。在这里,我们将讨论如何利用新的工具来描述基质的组成和功能,以便我们能够在体外设计和提供先进的基质,在体内优化组织和器官的再生。

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本文引用的文献

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Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow.骨髓层粘连蛋白影响造血干细胞和祖细胞的循环和归巢到骨髓。
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Functional proteomics of cellular mechanosensing mechanisms.细胞机械感知机制的功能蛋白质组学。
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Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials.用于终末期肾病患者透析通路的生物工程人脱细胞血管:两项2期单臂试验。
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Evidence for Mechanisms Underlying the Functional Benefits of a Myocardial Matrix Hydrogel for Post-MI Treatment.心肌基质水凝胶用于心肌梗死后治疗功能益处的潜在机制证据。
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