Department of Medicine - DIMED, Surgical Pathology & Cytopathology Unit, University of Padova, Padova, Italy.
Best Pract Res Clin Gastroenterol. 2013 Apr;27(2):205-23. doi: 10.1016/j.bpg.2012.12.007.
Gastric cancer is the final step in a multi-stage cascade triggered by long-standing inflammatory conditions (particularly Helicobacter pylori infection) resulting in atrophic gastritis and intestinal metaplasia: these lesions represent the cancerization field in which (intestinal-type) gastric cancer develops. Intraepithelial neoplasia is consistently recognized as the phenotypic bridge between atrophic/metaplastic lesions and invasive cancer. This paper addresses the epidemiology, pathology, molecular profiling, and clinical management of advanced precancerous gastric lesions.
胃癌是由长期炎症状态（尤其是幽门螺杆菌感染）引发的多阶段级联反应的最后一步，导致萎缩性胃炎和肠化生：这些病变代表了（肠型）胃癌发生的癌变领域。上皮内瘤变一直被认为是萎缩/化生病变与浸润性癌之间的表型桥梁。本文讨论了进展期癌前胃病变的流行病学、病理学、分子特征和临床管理。
