Bas Bilge, Dinc Bulent
Bulent Dinc, Department of General Surgery, Health Sciences University, Antalya Training and Research Hospital, 07100 Antalya, Turkey,
Croat Med J. 2020 Aug 31;61(4):319-325. doi: 10.3325/cmj.2020.61.319.
To assess the relationship between Helicobacter pylori (H. pylori) infection and atrophic gastritis (AG) and intestinal metaplasia (IM) development and to assess the rate of dysplasia or gastric cancer development in patients with AG and/or IM.
This retrospective endoscopic follow-up study enrolled 2214 patients. The patients were followed for at least five years between 2007 and 2017 at the Department of Endoscopy at Antalya Ataturk Government Hospital. The results of third-year and five-year surveillance biopsy were assessed.
The mean follow-up time was 7.77 ± 2.78 years. H. pylori was histologically assessed in 1417 (64.6%) patients. Of 198 patients with severe H. pylori infection, 32 (16%) and 139 (70.3%) developed extensive AG and extensive IM, respectively. There was a significant relationship between H. pylori density and AG and IM degrees. High grade dysplasia, early gastric cancer, and advanced gastric cancer were diagnosed in 73 patients with median age 58.2 (28-80) years, and the incidence rate was 3.29% (73/2214). The annual incidence of gastric neoplastic lesions was 0.46% in total, 0.08% for early GC, and 0.02% for advanced gastric cancer.
H. pylori infection has an important role in the development of AG and IM. H. pylori density is directly related to atrophy and metaplasia degree.
评估幽门螺杆菌（H. pylori）感染与萎缩性胃炎（AG）及肠化生（IM）发展之间的关系，并评估AG和/或IM患者发育异常或胃癌的发生率。
这项回顾性内镜随访研究纳入了2214例患者。2007年至2017年期间，这些患者在安塔利亚阿塔图尔克政府医院内镜科接受了至少五年的随访。评估了第三年和第五年监测活检的结果。
平均随访时间为7.77±2.78年。对1417例（64.6%）患者进行了幽门螺杆菌的组织学评估。在198例幽门螺杆菌严重感染患者中，分别有32例（16%）和139例（70.3%）发生了广泛的AG和广泛的IM。幽门螺杆菌密度与AG和IM程度之间存在显著关系。73例患者被诊断为高级别发育异常、早期胃癌和进展期胃癌，中位年龄为58.2岁（28 - 80岁），发病率为3.29%（73/2214）。胃肿瘤性病变的年总发病率为0.46%，早期胃癌为0.08%，进展期胃癌为0.02%。
幽门螺杆菌感染在AG和IM的发展中起重要作用。幽门螺杆菌密度与萎缩和化生程度直接相关。
