Department of Communication Sciences & Disorders, The University of Iowa, Iowa City, Iowa 52242, USA.
J Voice. 2013 Jul;27(4):441-7. doi: 10.1016/j.jvoice.2013.03.013.
The purpose of this study was to determine the conditions needed to elicit phonation from excised human larynges and the resultant range of phonations produced; compare that with similar information previously obtained from canine, pig, sheep, and cow; and relate those findings to previously reported information about viscoelastic properties of the vocal fold tissue (ie, stress-strain curves and Young's modulus).
Six human larynges of the geriatric group (age range, 70-89) were mounted on the bench without supraglottic structures, and phonation was achieved with the flow of heated and humidified air through the tracheal tube. Using various sutures to mimic the function of the laryngeal muscles, the larynges were put through a series of sustained oscillations with adduction as a control parameter.
The human larynges oscillated with an average frequency that was close to the canine larynges, but the oscillation behavior and wide frequency range were similar to those of pig larynges. The similarity of the wide vibration frequency ranges of human and pig larynges may be because of the nonlinear behavior of their elasticity, which is related to the high collagen content of the vocal folds. On the contrary, other species with limited frequency ranges showed almost linear stress-strain curves because of the higher elastin and lower collagen contents.
The physiological differences in the linearity and ranges of oscillation of excised larynges reported in this study and previous studies are reflective of the tissue composition and mechanics.
本研究旨在确定从人喉切除组织中引发发声所需的条件以及产生的发声范围；并与先前从犬、猪、羊和牛获得的类似信息进行比较；并将这些发现与先前关于声带组织粘弹性的报告信息（即应力-应变曲线和杨氏模量）相关联。
将 6 个人的老年组（年龄范围 70-89 岁）喉切除组织安装在没有会厌结构的实验台上，通过气管管内的热湿气流实现发声。使用各种缝线模拟喉肌的功能，将喉切除组织通过一系列带有内收动作的持续振荡进行处理。
人喉切除组织的平均频率与犬喉切除组织相近，但振荡行为和宽频范围与猪喉切除组织相似。人喉和猪喉切除组织宽振频范围相似可能是因为它们的弹性具有非线性行为，这与人声带中的高胶原蛋白含量有关。相比之下，由于弹性蛋白含量较高、胶原蛋白含量较低，其他频率范围有限的物种的应力-应变曲线几乎呈线性。
本研究及以往研究中报道的人喉切除组织的线性和振荡范围的生理差异反映了组织成分和力学特性的差异。
