Carasatorre M, Ramírez-Amaya V, Díaz Cintra S
Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología (INB), Campus UNAM-Juriquilla, Querétaro, México.
Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología (INB), Campus UNAM-Juriquilla, Querétaro, México.
Neurologia. 2016 Oct;31(8):543-9. doi: 10.1016/j.nrl.2012.12.005. Epub 2013 Jun 28.
Long-lasting memory formation requires that groups of neurons processing new information develop the ability to reproduce the patterns of neural activity acquired by experience.
Changes in synaptic efficiency let neurons organise to form ensembles that repeat certain activity patterns again and again. Among other changes in synaptic plasticity, structural modifications tend to be long-lasting which suggests that they underlie long-term memory. There is a large body of evidence supporting that experience promotes changes in the synaptic structure, particularly in the hippocampus.
Structural changes to the hippocampus may be functionally implicated in stabilising acquired memories and encoding new information.
持久的记忆形成需要处理新信息的神经元群体发展出重现通过经验获得的神经活动模式的能力。
突触效率的变化使神经元组织起来形成集合，反复重复某些活动模式。在突触可塑性的其他变化中，结构修饰往往是持久的，这表明它们是长期记忆的基础。有大量证据支持经验会促进突触结构的变化，特别是在海马体中。
海马体的结构变化可能在稳定获得的记忆和编码新信息方面具有功能上的牵连。
