Paulsen O, Moser E I
MRC Anatomical Neuropharmacology Unit, University Dept of Pharmacology, Oxford, UK.
Trends Neurosci. 1998 Jul;21(7):273-8. doi: 10.1016/s0166-2236(97)01205-8.
The current view of the role of GABAergic interneurones in cortical-network function has shifted from one of merely dampening neuronal activity to that of an active role in information processing. In this review, we explore a potential role of hippocampal GABAergic interneurones in providing spatial and temporal conditions for modifications of synaptic weights during hippocampus-dependent memory processes. We argue that knowledge of spatiotemporal activity patterns in distinct classes of interneurone is essential to understanding the cellular mechanisms underlying learning and memory.
目前关于γ-氨基丁酸能中间神经元在皮质网络功能中作用的观点，已从仅仅抑制神经元活动转变为在信息处理中发挥积极作用。在本综述中，我们探讨了海马体γ-氨基丁酸能中间神经元在海马体依赖性记忆过程中为突触权重的改变提供时空条件方面的潜在作用。我们认为，了解不同类型中间神经元的时空活动模式对于理解学习和记忆背后的细胞机制至关重要。
