Kumagai K, Yasui A, Nishida Y, Sanada Y, Masuo K, Yoshitoshi A, Karasawa Y
Dept. of Surgery, Showa Univ. Toyosu Hospital.
Gan No Rinsho. 1990 Aug;36(9):979-84.
A study has been made of type and prognosis of esophageal invasions exhibited by gastric carcinomas sited in the cardiac part of the stomach. Examined were 14 such cases of an adenocarcinoma with an esophageal invasion. Histopathologically, the invasions into the esophagus were classified into 4 types of severity, from 1 to 4, according to the depth of the invasion into the esophago-gastric junction (EGJ) and the pattern of the invasion to the oral side (thoracic side). The prognosis was found to be good for EGJ invasion that had penetrated to the pm and/or sm layer only, whereas it was very bad if the invasion had penetrated the entire EGJ wall (the pm, sm, mp, and the sa) and the infiltrative pattern had reached the oral side (thoracic side). Almost all patients given a type 4 classification soon had a recurrence after surgery and did not live beyond two years. Thus, a close relationship has been noted between the type of invasion into the esophagus and the prognosis.
对位于胃贲门部的胃癌所表现出的食管侵犯类型及预后进行了一项研究。研究了14例伴有食管侵犯的腺癌病例。组织病理学上,根据对食管胃交界(EGJ)的侵犯深度以及向口腔侧(胸段侧)的侵犯模式,将食管侵犯分为从1到4级的4种严重程度类型。结果发现,仅穿透至黏膜下层(pm)和/或黏膜肌层(sm)的EGJ侵犯预后良好,而如果侵犯穿透了整个EGJ壁(pm、sm、肌层(mp)和浆膜层(sa))且浸润模式已达口腔侧(胸段侧),则预后非常差。几乎所有被分类为4级的患者术后很快复发,生存期不超过两年。因此,已注意到食管侵犯类型与预后之间存在密切关系。