Sato K, Ushijima T, Ohbayashi Y, Sato H, Urabe A
Department of Hematology and Oncology, Kanto-Teishin Hospital.
Rinsho Ketsueki. 1990 Apr;31(4):521-2.
Two cases of chronic myelomonocytic leukemia (CMML) which were successfully treated with low dose etoposide are reported. One case was treated with oral etoposide in daily dose of 25 mg for 3d a week, another case in dose of 50 mg/day. Their white blood cell counts became normal and monocytes decreased after the treatment with etoposide. In the second case, blasts in peripheral blood disappeared and thrombocytopenia was improved. The experience of these cases suggests that low dose etoposide is an useful treatment for CMML.
报告了两例慢性粒单核细胞白血病(CMML)患者经低剂量依托泊苷成功治疗的病例。一例患者口服依托泊苷,每日剂量25mg,每周服用3天;另一例患者剂量为50mg/天。使用依托泊苷治疗后,他们的白细胞计数恢复正常,单核细胞减少。在第二例患者中,外周血中的原始细胞消失,血小板减少症得到改善。这些病例的经验表明,低剂量依托泊苷是治疗CMML的一种有效方法。