慢性口服依托泊苷治疗后发生的急性粒单核细胞白血病：MLL和LTG9基因是依托泊苷的作用靶点吗？
Acute myelomonocytic leukemia after treatment with chronic oral etoposide: are MLL and LTG9 genes targets for etoposide?
作者信息
Goto H, Shimazaki C, Tatsumi T, Yamagata N, Inaba T, Fujita N, Moriguchi T, Yamamoto K, Seto M, Ueda R
机构信息
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
出版信息
Int J Hematol. 1994 Aug;60(2):145-9.
A patient with secondary acute myelomonocytic leukemia after treatment with chronic oral etoposide (VP-16) for lung cancer is reported. The leukemic cells showed a t(9;11)(p22;q23) translocation. Southern blot analysis revealed the rearrangement of the MLL (ALL-1/HRX) gene at 11q23. Reverse transcriptase-polymerase chain reaction (RT-PCR) revealed a chimeric mRNA between the MLL gene at 11q23 and LTG9 (MLLT3/AF-9) gene at 9p22. The patient was successfully treated with a VP-16 based regimen. This case is instructive in the understanding of the leukemogenesis of VP-16-related leukemias.
报告了一名肺癌患者，在用慢性口服依托泊苷（VP - 16）治疗后发生继发性急性粒单核细胞白血病。白血病细胞显示出t(9;11)(p22;q23)易位。Southern印迹分析显示11q23处的MLL（ALL - 1/HRX）基因重排。逆转录聚合酶链反应（RT - PCR）显示11q23处的MLL基因与9p22处的LTG9（MLLT3/AF - 9）基因之间存在嵌合mRNA。该患者接受基于VP - 16的方案治疗成功。此病例对于理解VP - 16相关白血病的白血病发生具有指导意义。
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