Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham 27710, North Carolina, USA.
Nat Rev Drug Discov. 2013 Jul;12(7):526-42. doi: 10.1038/nrd4003.
Approximately 50% of all patients with cancer receive radiation therapy at some point during the course of their treatment, and the majority of these patients are treated with curative intent. Despite recent advances in the planning of radiation treatment and the delivery of image-guided radiation therapy, acute toxicity and potential long-term side effects often limit the ability to deliver a sufficient dose of radiation to control tumours locally. In the past two decades, a better understanding of the hallmarks of cancer and the discovery of specific signalling pathways by which cells respond to radiation have provided new opportunities to design molecularly targeted therapies to increase the therapeutic window of radiation therapy. Here, we review efforts to develop approaches that could improve outcomes with radiation therapy by increasing the probability of tumour cure or by decreasing normal tissue toxicity.
大约 50%的癌症患者在治疗过程中的某个阶段接受放射治疗，其中大多数患者接受的是根治性治疗。尽管放射治疗计划和图像引导放射治疗的最近进展，急性毒性和潜在的长期副作用往往限制了提供足够剂量的辐射以控制局部肿瘤的能力。在过去的二十年中，对癌症特征的更好理解以及发现细胞对辐射作出反应的特定信号通路，为设计分子靶向治疗以增加放射治疗的治疗窗口提供了新的机会。在这里，我们综述了通过提高肿瘤治愈率或降低正常组织毒性来改善放射治疗结果的方法。
