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多功能金纳米团簇作为用于疾病管理的下一代诊疗平台。

Multifunctional gold nanoclusters as next-generation theranostic platforms for disease management.

作者信息

Sun Yan, Chen Yining, Hu Xiaoyang, Liu Ai, He Lizhong, Dai Afang, Wei Tiansheng, Wang Shoucui, Gan Zibao

机构信息

Key Laboratory of Advanced Biomaterials and Nanomedicine in Universities of Shandong, Linyi University, Linyi 276000, China.

Philippine Christian University Center for International Education, Manila 1004, Philippines.

出版信息

Int J Pharm X. 2025 Jul 21;10:100361. doi: 10.1016/j.ijpx.2025.100361. eCollection 2025 Dec.

DOI:10.1016/j.ijpx.2025.100361
PMID:40777085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12329304/
Abstract

Gold nanoclusters (GNCs), typically consisting of a few to a few hundred gold atoms with a core size below 3 nm, have emerged as revolutionary nanomaterials due to their diverse and tunable molecule-like properties, high photostability, and excellent biocompatibility. These advantages establish GNCs as next-generation theranostic platforms for precise nanomedicine applications. In this review, we summarize the typical synthesis methodologies, focus on their latest cutting-edge applications in disease management, including bioimaging, sensing, drug delivery, cancer, and other diseases. Finally, we discuss the challenges and opportunities associated with GNCs as theranostic agents. It is envisioned that this review aims to guide the rational design of GNC-based smart platforms and stimulate interdisciplinary innovation in personalized medicine.

摘要

金纳米团簇（GNCs）通常由几个到几百个金原子组成，核心尺寸小于3纳米，由于其具有多样且可调节的类分子性质、高光稳定性和出色的生物相容性，已成为具有革命性的纳米材料。这些优势使金纳米团簇成为用于精准纳米医学应用的下一代治疗诊断平台。在本综述中，我们总结了典型的合成方法，重点介绍了它们在疾病管理中的最新前沿应用，包括生物成像、传感、药物递送、癌症及其他疾病。最后，我们讨论了金纳米团簇作为治疗诊断剂所面临的挑战和机遇。预计本综述旨在指导基于金纳米团簇的智能平台的合理设计，并激发个性化医学中的跨学科创新。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/a69fe21599bc/gr13.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/129f1220606f/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/0c2ace07f14f/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/fadf89d4d6a4/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/5c7ada9792a9/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/a69fe21599bc/gr13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/389c40a61837/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/1ff8a8e2aab5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/52580a7ce617/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/7e74fd141dbc/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/c4777c8b7117/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/5fb37a0182a3/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/ce58974f061b/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/e6d3b08f7da3/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/b95bb591c7a8/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/129f1220606f/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/0c2ace07f14f/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/fadf89d4d6a4/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/5c7ada9792a9/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a6d/12329304/a69fe21599bc/gr13.jpg

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本文引用的文献

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Engineering ultrasmall gold nanoclusters: tailored optical modulation for phototherapeutic and multimodal biomedical applications.工程化超小金纳米团簇：用于光疗和多模态生物医学应用的定制光学调制
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Enhanced Sonodynamic Therapy via Au Nanoclusters Deposited on TiO Nanosheets.通过沉积在TiO纳米片上的金纳米团簇增强声动力疗法。
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用于纳米医学的超小无机纳米颗粒的进展：从诊断到治疗
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