妊娠期使用格列本脲的药物治疗方法。
A pharmacologic approach to the use of glyburide in pregnancy.
机构信息
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and the Department of Pharmacy and Obstetrics & Gynecology, University of Washington, Seattle, Washington, for the Obstetric-Fetal Pharmacology Research Unit Network.
出版信息
Obstet Gynecol. 2013 Jun;121(6):1309-1312. doi: 10.1097/AOG.0b013e31829007f0.
Abstract
Despite widespread use of glyburide to treat pregnancy-related hyperglycemia, the dosing regimen is based in large part on pharmacokinetic and pharmacodynamic studies in men and nonpregnant women. Like many medications used by pregnant women, adequate pharmacokinetic and pharmacodynamic data in pregnancy have been sorely lacking. This lack of information can lead to both overdosing with excessive side effects and underdosing with an inadequate therapeutic response. Both of these problems may apply to glyburide use in pregnancy. This commentary provides a pharmacologic basis for altering the glyburide administration regimen. Taking glyburide 1 hour before a meal may improve efficacy in patients with pregnancy-related hyperglycemia.
摘要
尽管临床上广泛使用格列本脲治疗与妊娠相关的高血糖，但该药物的剂量方案在很大程度上是基于男性和非妊娠女性的药代动力学和药效学研究。像许多孕妇使用的药物一样，妊娠期间的药代动力学和药效学数据严重缺乏。这种信息的缺乏可能导致药物过量和副作用过多，也可能导致药物剂量不足和治疗效果不理想。这两个问题都可能适用于妊娠期间使用格列本脲。本文评论为改变格列本脲的给药方案提供了药理学基础。与进餐同时服用格列本脲可能会提高与妊娠相关的高血糖患者的疗效。
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