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[泼尼松龙对人体受刺激胃黏膜酸分泌的急性作用研究]

[Examination of the acute effect of prednisolone on the acid secretion of the stimulated gastric mucosa in man].

作者信息

Mertz D P, Papavassiliou K

出版信息

MMW Munch Med Wochenschr. 1975 Apr 4;117(14):575-8.

PMID:238129
Abstract

In comparison with the maximal acid stimulation produced by intravenous infusion of histalog (2 mg/kg bw/h), a single intravenous injection of 25 mg prednisolone during maximal acid stimulation produced by pentagastrin (1.5 mug/kg bw/h) does not cause a significant change of secretion rate or ionic composition of gastric juice in man. This suggests that there is a greater dependence of histalog stimulation than of pentagastrin stimulation on the normal secretion of glucocorticoids.

摘要

与静脉输注组胺甲磺酸盐(2毫克/千克体重/小时)所产生的最大酸刺激相比,在五肽胃泌素(1.5微克/千克体重/小时)产生的最大酸刺激期间单次静脉注射25毫克泼尼松龙,不会引起人体胃液分泌速率或离子组成的显著变化。这表明,与五肽胃泌素刺激相比,组胺甲磺酸盐刺激对糖皮质激素正常分泌的依赖性更大。

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