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[泼尼松龙对人体受刺激胃黏膜酸分泌的急性作用研究]

[Examination of the acute effect of prednisolone on the acid secretion of the stimulated gastric mucosa in man].

作者信息

Mertz D P, Papavassiliou K

出版信息

MMW Munch Med Wochenschr. 1975 Apr 4;117(14):575-8.

PMID:238129
Abstract

In comparison with the maximal acid stimulation produced by intravenous infusion of histalog (2 mg/kg bw/h), a single intravenous injection of 25 mg prednisolone during maximal acid stimulation produced by pentagastrin (1.5 mug/kg bw/h) does not cause a significant change of secretion rate or ionic composition of gastric juice in man. This suggests that there is a greater dependence of histalog stimulation than of pentagastrin stimulation on the normal secretion of glucocorticoids.

摘要

与静脉输注组胺甲磺酸盐(2毫克/千克体重/小时)所产生的最大酸刺激相比,在五肽胃泌素(1.5微克/千克体重/小时)产生的最大酸刺激期间单次静脉注射25毫克泼尼松龙,不会引起人体胃液分泌速率或离子组成的显著变化。这表明,与五肽胃泌素刺激相比,组胺甲磺酸盐刺激对糖皮质激素正常分泌的依赖性更大。

相似文献

1
[Examination of the acute effect of prednisolone on the acid secretion of the stimulated gastric mucosa in man].[泼尼松龙对人体受刺激胃黏膜酸分泌的急性作用研究]
MMW Munch Med Wochenschr. 1975 Apr 4;117(14):575-8.
2
Potentiation between pentagastrin and histamine in stimulation of secretion from totally isolated ex vivo canine stomach.五肽胃泌素与组胺对离体犬全胃分泌的协同刺激作用。
Pharmacology. 1972;7(5):357-65. doi: 10.1159/000136310.
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Effects of atropine on histamine-induced human gastric secretion.阿托品对组胺诱导的人胃分泌的影响。
Scand J Gastroenterol. 1969;4(3):257-63.
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[Effect of nicotine on the production of gastric acid (author's transl)].尼古丁对胃酸分泌的影响(作者译)
Med Klin. 1976 Jan 23;71(4):147-55.
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Gastric secretory response to cholinergic stimulation in rats chronically pretreated with pentagastrin or histamine in depot form.用五肽胃泌素或长效组胺对大鼠进行长期预处理后,大鼠对胆碱能刺激的胃分泌反应。
Digestion. 1976;14(4):368-71. doi: 10.1159/000197954.
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Comparison of the gastric secretory responses following the administration of histamine acid phosphate and pentagastrin by separate continuous intravenous infusions or by a step-test method.
Scand J Gastroenterol. 1970;5(5):449-57.
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Sodium pentobarbital depression of histamine- or insulin-stimulated gastric secretion.戊巴比妥钠对组胺或胰岛素刺激的胃分泌的抑制作用。
Am J Physiol. 1967 May;212(5):1001-6. doi: 10.1152/ajplegacy.1967.212.5.1001.
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[Acid- and electrolyte secretion of the gastric mucosa following stimulation with histamine, histalog, and pentagastrin].[组胺、氨甲酰甲胆碱和五肽胃泌素刺激后胃黏膜的酸和电解质分泌]
Dtsch Z Verdau Stoffwechselkr. 1972;32(1):201-3.
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Dose-response studies of gastric secretion of sodium, potassium, calcium, inorganic phosphorus, and magnesium after stimulation with pentagastrin.用五肽胃泌素刺激后胃钠、钾、钙、无机磷和镁分泌的剂量反应研究。
Scand J Gastroenterol. 1970;5(7):609-12.
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Effects of anticholinergic agents on gastric secretion stimulated by pentagastrin infusion.抗胆碱能药物对五肽胃泌素输注刺激的胃酸分泌的影响。
Tijdschr Gastroenterol. 1974;17(1):7-16.

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