Nguyen Nam D, Tucker Matthew A, Stickgold Robert, Wamsley Erin J
Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA.
Sleep. 2013 Jul 1;36(7):1051-1057. doi: 10.5665/sleep.2808.
Several studies have now demonstrated that spatial information is processed during sleep, and that posttraining sleep is beneficial for human navigation. However, it remains unclear whether the effects of sleep are primarily due to consolidation of cognitive maps, or alternatively, whether sleep might also affect nonhippocampal aspects of navigation (e.g., speed of motion) involved in moving through a virtual environment.
Participants were trained on a virtual maze navigation task (VMT) and then given a memory test following either a day of wakefulness or a night of sleep. Subjects reported to the laboratory for training at either 10:00am or 10:00pm, depending on randomly assigned condition, and were tested 11 h later. Overnight subjects slept in the laboratory with polysomnography.
A hospital-based academic sleep laboratory.
Thirty healthy college student volunteers.
N/A.
Point-by-point position data were collected from the VMT. Analysis of the movement data revealed a sleep-dependent improvement in maze completion time (P < 0.001) due to improved spatial understanding of the maze layout, which led to a shortening of path from start to finish (P = 0.01) rather than faster exploration speed through the maze (P = 0.7).
We found that overnight sleep benefitted performance, not because subjects moved faster through the maze, but because they were more accurate in navigating to the goal. These findings suggest that sleep enhances participants' knowledge of the spatial layout of the maze, contributing to the consolidation of hippocampus-dependent spatial information.
Nguyen ND; Tucker MA; Stickgold R; Wamsley EJ. Overnight sleep enhances hippocampus-dependent aspects of spatial memory. 2013;36(7):1051-1057.
多项研究现已表明，睡眠过程中会处理空间信息，且训练后的睡眠对人类导航有益。然而，睡眠的影响主要是由于认知地图的巩固，还是睡眠也可能影响在虚拟环境中移动所涉及的导航的非海马体方面（例如运动速度），目前尚不清楚。
参与者接受虚拟迷宫导航任务（VMT）训练，然后在清醒一天或睡眠一晚后进行记忆测试。根据随机分配的条件，受试者于上午10:00或晚上10:00到实验室接受训练，并在11小时后进行测试。过夜受试者在实验室进行多导睡眠监测。
一家医院的学术睡眠实验室。
30名健康大学生志愿者。
无。
从VMT收集逐点位置数据。对运动数据的分析显示，由于对迷宫布局的空间理解得到改善，迷宫完成时间有睡眠依赖性改善（P < 0.001），这导致从起点到终点的路径缩短（P = 0.01），而不是通过迷宫的探索速度加快（P = 0.7）。
我们发现过夜睡眠有利于提高表现，不是因为受试者在迷宫中移动得更快，而是因为他们在导航到目标时更准确。这些发现表明，睡眠增强了参与者对迷宫空间布局的了解，有助于巩固海马体依赖的空间信息。
Nguyen ND; Tucker MA; Stickgold R; Wamsley EJ. 过夜睡眠增强海马体依赖的空间记忆方面。2013;36(7):1051 - 1057。
