Morukov B V, Popov I N, Levin G, Markin A A, Zhuravleva O A, Kuzichkin D S
Aviakosm Ekolog Med. 2013 Mar-Apr;47(2):48-50.
In the 520-d chamber experiment within the international project Mars-500 blood samples of 6 male test-subjects of 28 to 39 years of age were analyzed for water-soluble antioxidants: total bilirubin and uric acid; in addition, total antioxidant capacity of blood plasma was determined. Maximal values of these parameters were associated with the most stressful periods of the experiment, i.e. adaptation to the life in isolation and confinement, simulation of the egress onto Martian surface, and change of the diet. On attainment of the homeostatic equilibrium the parameters stabilized on levels slightly lower relative to baseline (pre-isolation) values. Therefore, dynamics of the water-soluble antioxidants reflected adequately the homeostatic reactions to and compensation by organism of the effects of the 520-day life in isolation and confinement.
在国际火星-500项目的520天舱内实验中，对6名年龄在28至39岁之间的男性受试对象的血样进行了水溶性抗氧化剂分析：总胆红素和尿酸；此外，还测定了血浆的总抗氧化能力。这些参数的最大值与实验中压力最大的时期相关，即适应隔离和封闭生活、模拟踏上火星表面以及饮食变化。达到体内平衡后，这些参数稳定在略低于基线（隔离前）值的水平。因此，水溶性抗氧化剂的动态变化充分反映了机体对520天隔离和封闭生活影响的体内平衡反应及补偿情况。
