State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
Org Lett. 2013 Jul 19;15(14):3570-3. doi: 10.1021/ol401411m. Epub 2013 Jul 1.
A new pentacyclic (5/6/6/6/7) Lycopodium alkaloid named isopalhinine A (1), which possesses a sterically congested architecture built with a tricyclo[4.3.1.0(3,7)]decane (isotwistane) moiety and a 1-azabicyclo[4.3.1]decane moiety, and palhinines B (2) and C (3) were isolated from Palhinhaea cernua. The structure and absolute configuration of 1 were elucidated by a combination of NMR spectra, optical rotation calculation, and X-ray diffraction experiment. A possible biogenetic pathway was also proposed.
从翠柏 Palhinhaea cernua 中分离得到了一个新的五环（5/6/6/6/7）石松生物碱命名为异石松宁 A（1），它具有一个由三环[4.3.1.0(3,7)]癸烷（异扭曲烷）部分和一个 1-氮杂双环[4.3.1]癸烷部分组成的空间拥挤的架构，还分离得到了 palhinines B（2）和 C（3）。通过 NMR 光谱、旋光计算和 X 射线衍射实验的组合，阐明了 1 的结构和绝对构型。还提出了一个可能的生物合成途径。
