白头翁 A，一种来自白头翁的新型生物碱。

Palhinine A, a novel alkaloid from Palhinhaea cernua.

机构信息

Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

Org Lett. 2010 Sep 3;12(17):3922-5. doi: 10.1021/ol101602n.

DOI:10.1021/ol101602n

PMID:20690613

Abstract

Palhinine A, a novel C(16)N-type Lycopodium alkaloid with a unique 5/6/6/9 tetracyclic ring system, was isolated from the whole plant of Palhinhaea cernua L. (Lycopodiaceae). Its structure was elucidated by spectroscopic methods, and the absolute configuration was determined by single-crystal X-ray diffraction analysis using the Flack parameter. Palhinine A is reported as the first example of Lycopodium alkaloids of which C-16 is fused to a new ring through a C-16-C-4 lingkage.

摘要

从翠柏 Palhinhaea cernua L.（石松科）全草中分离得到了一种新型 C(16)N 型石松生物碱 palhinine A，具有独特的 5/6/6/9 四环体系。其结构通过光谱方法阐明，并通过单晶 X 射线衍射分析利用 Flack 参数确定了绝对构型。palhinine A 是第一个 C-16 通过 C-16-C-4 键合与新环稠合的石松生物碱的实例。