法匹拉韦，来自牵牛花（Pharbitis nil）的一种异贝壳杉烯酸。

Pharbinilic acid, an allogibberic acid from morning glory (Pharbitis nil).

机构信息

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.

出版信息

J Nat Prod. 2013 Jul 26;76(7):1376-9. doi: 10.1021/np400326e. Epub 2013 Jul 1.

DOI:10.1021/np400326e

PMID:23815260

Abstract

Pharbinilic acid (1), the first naturally occurring allogibberic acid, was isolated from ethanol extracts of morning glory (Pharbitis nil) seeds. Its absolute configuration was determined by NOESY NMR and ECD experiments. Compound 1 showed weak cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cells and weakly inhibited nitric oxide production in lipopolysaccharide-activated BV-2 microglia cells.

摘要

法匹拉林酸（1），第一个天然全异戊烯基 Gibberic 酸，从牵牛花（Pharbitis nil）种子的乙醇提取物中分离得到。其绝对构型通过 NOESY NMR 和 ECD 实验确定。化合物 1 对 A549、SK-OV-3、SK-MEL-2 和 HCT-15 细胞表现出微弱的细胞毒性，并能抑制脂多糖激活的 BV-2 小胶质细胞中一氧化氮的产生。