Instituto de Medicina Tropical, Alexander von Humboldt, Universidad Peruana, Cayetano Heredia in Lima, Lima, Peru.
Pathog Glob Health. 2013 Jun;107(4):202-6. doi: 10.1179/2047773213Y.0000000091.
Human T lymphotropic virus type 1 (HTLV-1) infection displays variable clinical manifestations. These include inflammatory diseases such as HTLV-1 associated myelopathy (HAM) or immunosuppressive conditions such as Strongyloides stercoralis hyperinfection. The viral protein, Tax causes activation and proliferation of T cells. We hypothesize that the expression of Tax in T cell subsets characterizes the clinical manifestations of HTLV-1. To test this hypothesis, we measured T helper 1 effector cells and regulatory T cells (Tregs) among Tax expressing lymphocytes from peripheral blood mononuclear cells (PBMCs) of 32 HTLV-1 infected patients with HAM, with S. stercoralis co-infection or with asymptomatic infection. We observed increased ratios of Th1/Treg among Tax expressing lymphocytes in HAM patients. These data suggest that the expression of Tax among the different target cells may explain the variable presentation of HTLV-1.
人类 T 淋巴细胞白血病病毒 1 型（HTLV-1）感染表现出不同的临床表现。这些包括炎症性疾病，如 HTLV-1 相关脊髓病（HAM）或免疫抑制状态，如 Strongyloides stercoralis 重度感染。病毒蛋白 Tax 导致 T 细胞的激活和增殖。我们假设 Tax 在 T 细胞亚群中的表达特征可以描述 HTLV-1 的临床表现。为了验证这一假设，我们测量了来自 32 名 HTLV-1 感染患者外周血单个核细胞（PBMCs）中表达 Tax 的淋巴细胞中的辅助性 T 细胞效应细胞和调节性 T 细胞（Tregs）。这些患者中有的患有 HAM，有的患有 Strongyloides stercoralis 合并感染，有的则无症状感染。我们观察到在 HAM 患者中，表达 Tax 的淋巴细胞中 Th1/Treg 的比值增加。这些数据表明，不同靶细胞中 Tax 的表达可能解释了 HTLV-1 的不同表现。
